Prevention Of Mother Transmission Of Hiv - 3471 Words

Background: The 2013 WHO guidelines incorporated simplified and more effective antiretroviral regimens for the purposes of preventing mother-to-child transmission of HIV. With ideal implementation of these recommendations, perinatal HIV transmission could be reduced to less than 2%. However, loss to follow-up (LTFU) has the potential to erode the success of programs and a number of studies report high rates of LTFU within the prevention of mother-to-child transmission (PMTCT) care cascade. We evaluated the timing and magnitude of LTFU in a large programmatic PMTCT cohort in Nigeria in order to focus future efforts to reduce loss in this high burden setting. Methods: From 2004-2014, the APIN/Harvard PEPFAR program supported antenatal HIV screening for nearly one million pregnant women and provided PMTCT care to over 30,000 women. The care cascade for women enrolling in the PMTCT program includes antenatal, delivery, and infant follow-up services through 12-18 months of life. In this retrospective cohort analysis, we examined data collected between 2004-2014 from 31 clinical sites in Nigeria and assessed the numbers of mothers and infants enrolled and LTFU at various points along the care cascade. Results: Among 31,504 women (median age 30, IQR: 27-34) entering PMTCT care during the antenatal period, 20,679 (66%) completed the entire cascade of services including antenatal, delivery, and at least one infant follow-up visit. The median gestational age at presentationShow MoreRelatedThe Effects Of HIV Testing In Pregnant Women1294 Words   |  6 PagesHIV can be transmitted from an HIV infected mother to her newborn child. According to the World Health Organization (WHO), without antiretroviral treatment of the mother, up to 30% of infants born to HIV positive mother’s become infected with HIV themselves. The number increases to 35%-50% if the mother breastfeeds the baby (aidsinfonet, 2014). The risk of HIV transmission to the infant from the mother decreases significantly if the mother used antiretrovirals throughout pregnancy and labor. If theRead MoreRole Of And Nature Of Public Health Research1251 Words   |  6 PagesTOPIC TITTLE: Elimination of the Mother To Child Transmission of HIV (eMTCT) program: An evaluation of practices by health care workers in selected Primary health care centers, Zambia. IMPORTANCE OF THE CHOSEN HEALTH ISSUE: In Zambia, 13% of adults age 15-49 are infected with HIV. 15% of them are women and 11 percent are men (dhsprogram.com, 2015). 16.4% of pregnant women attending antenatal clinics are HIV positive and 35% of all HIV exposed babies are born HIV positive (Unicef.org, 2015). 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In the beginning, HIV-1 enters the cells without producing instant damage but by entering the cells it can provoke intracellular signal cascades, which may assist the progress of viral replication. The external glycoprotein (gp120) and the transmembrane protein (gp141) are two molecules on the HIV-1 envelope that form the spi kes on the virion’s surface. In the entry process,